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Osteoporosis Model

Osteoporosis is a skeletal disorder characterised by reduced bone mineral content and altered bone structure leading to bone fragility and fractures.

Biograding Solutions offers a large variety of animal species, including rodents, rabbits, dogs, and primates. For both primary osteoporosis models and secondary osteoporosis models, the rat is usually the model of choice.

Animal Models

Primary osteoporosis models:   

  1. ● Oophorectomy in female rat
  2. ● Orchidectomy in male rat

Secondary osteoporosis models:

  1. ● Glucocorticoid treatment in rat – bone immobilisation in rat

Outcome Measurements:

  1. ● In vivo and ex-vivo BMD and BMC measurements of cortical and trabecular bones by DEXA, pQCT and microCT
  2. ● Biomechanical testing
  3. ● Physiological bone turnover markers (blood, urine)
  4. ● Ash chemical analysis
  5. ● Histomorphometry, histology
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