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Infection Models

Bone and joint inflammatory diseases encompass infections as well as their consequences (such as immunologically mediated local and systemic disease).

Our research models, discovery services, preclinical pharmacology models, safety assessment programs and full laboratory support services enable us to help your research in the field of bone and joint inflammatory diseases.

Biograding Solutions can provide you with infection and inflammation models to study a disease, a pharmaceutical product or can assist in improving your device.

Animal Models

Critical-size defects:

  1. ● Calvaria critical-size defect in rat and rabbit
  2. ● Mandibular critical-size defect in mini-pig and dog
  3. ● Femur critical-size defects in rat
  4. ● Ulna critical-size defects in rabbit
  5. ● Tibial critical-size defects in sheep and mini-pig

Osteotomy (Fracture and Segmental Bone Defects):

  1. ● Tibial osteotomy in mini-pig, sheep and goat
  2. ● Mandibular osteotomy in sheep

Outcome Measurements:

  1. ● In vivo and ex-vivo BMD and BMC measurements of cortical and trabecular bones by DEXA, pQCT, and microCT
  2. ● Biomechanical testing
  3. ● Physiological bone turnover markers (blood, urine)
  4. ● Ash chemical analysis
  5. ● Histomorphometry, histology
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Preclinical Histology Slides Performed

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